I just got the Supernatural RPG book. It uses the Serenity rules which we don't, but it does set up the world for Supernatural quite nicely. I would like to run a Hunters game set in the SPN 'Verse. I have the pdf of the White Wolf Hunters book. I've never really done anything with it, but I'm going to read up on it if you guys would like to play a Supernatural game.
I'd like to have the 4 of you be 2, 2 man teams. You'd join together to hunt a Big Bad.